Southampton knocks out the defending champions Arsenal out of the FA Cup competition at the fourth round courtesy of a first-half own goal by Gabriel.
The Saints were rewarded for their attacking intent in the opening period when Gabriel turned in Kyle Walker-Peters’ cross in the 24th minute.
It was the first goal Arsenal had conceded in 508 minutes as they suffered a first loss in seven matches.
Southampton will face another Premier League side, Wolves, in the next round.
With their next opponents enduring a poor run in the league and having struggled in their 1-0 win at non-league Chorley on Friday, the 1976 winners will fancy their chances of progressing further at Molineux.
The Saints also went close through Che Adams, whose low, angled strike was saved brilliantly by Bernd Leno, and James Ward-Prowse, who saw his delivery from a corner come off the bar.
In the second half, substitute striker Shane Long fell under a challenge in the box, but penalty appeals were waved away by referee Peter Bankes.
Arsenal were without forward Pierre-Emerick Aubameyang and midfielder Emile Smith Rowe, while another in-form player, Bukayo Saka, was only introduced in the second half.
Mikel Arteta’s Gunners side were tepid as an attacking force during the first 45 minutes, but looked more of a threat after the break.
However, Eddie Nketiah’s deflected shot in the 67th minute, which was superbly dealt with by home goalkeeper Fraser Forster, was their only effort of note.
REACTIONS FROM THE MANAGERS
Southampton boss Ralph Hasenhuttl speaking to BT Sport: “We had in the first half more punch and more power.
“In the second half it’s normal they have a lift. We must make the second goal – we made one or two chances. Shane Long should have got a penalty.
“We won the ball early on in the game, but our last decision-making was not always the best. In general, our work without the ball was good.
“It was a good team performance.”
Arsenal manager Arteta speaking to BT Sport: “We’re really sad to be out of the competition.
“We had issues in the first half and unforced errors as a result of the high press they do. In the second half, we had two or three big chances.
“It was an even game. In the first half, they won a lot of second balls. In the second half, we added more quality. We became more dominant and created chances, but it wasn’t enough.”
SOME KEY STATS
This was Southampton’s first FA Cup win over Arsenal at the fifth attempt.
Southampton have eliminated the holders from the competition for the first time since beating Tottenham in a replay in 1902. The Saints had lost their previous seven FA Cup fixtures against the holders.
This is the third time in the past four seasons that Arsenal have failed to make it to the fifth round of the FA Cup.
This was Gunners’ boss Arteta’s first defeat in the FA Cup as a player or manager in 15 games (W13 D1), since featuring in Arsenal’s 1-0 loss to Blackburn in February 2013.